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曹中炜

专家 博士生导师

科    室 西部妇幼医学研究院

是否在职 在职

招生方向 其它

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简介

1.职称:研究员

2.学历:博士

3.研究方向:主要研究肿瘤微环境如何诱导和维持肿瘤干细胞。我们认为肿瘤的血管微环境,特别是血管内皮细胞,通过分泌旁分泌因子来调控肿瘤干细胞的生长,迁移,化疗抗性等属性。这些发现从概念上改变了血管系统在肿瘤和纤维化中传输血液的传统观点。对血管微环境与肿瘤干细胞相互作用的系统研究加深了目前对肿瘤和纤维化病理机制的理解。所得的理论发现可用来设计特异性针对肿瘤和纤维化组织中畸变血管微环境的治疗手段,具有很强的应用价值。

4.邮件:zhongweicao@hotmail.com

5.教育经历:南京大学学士,硕士,加州大学戴维斯分校博士,斯坦福大学,康奈尔大学博士后,讲师

6.代表性论文

(1).  Cao Z,Lis R,Ginsberg M,Chavez D,Shido K,Rabbany SY,Fong GH,Sakmar TP,Rafii S,Ding BS.Targeting of the pulmonary capillary vascular niche promotes lung alveolarreparir and ameliorates fibrosis. Nat Med 2016, 22(2): 154-62.PMID 26779814


(2).  Cao Z, Ding BS,Guo P, Lee SL, Butler JM, Casey SC, Simons M, Tam W, Felsher DW, Shido K, Scandura JM, Rafii S. Angiocrine signals from tumor vascularniche induce B-Cell lymphoma invasiveness and chemoresistance. CancerCell 2014, 25(3): 1-16. PMID 24651014


Highlighted in 1) Cancer Cell 2014, 25 (3),261–263; 2) Nature Reviews Cancer14, 298 (2014) doi:10.1038/nrc3730; 3)  Science Signaling 2014, 7 (319): p. ec85.


(3).  Cao Z#, Ding BS#,Lis R, Nolan DJ, Guo P, Simons M, Penfold M, Shido K, Rabbany SY, and Rafii, S.Divergent angiocrine signals from vascular niche balance liver regeneration andfibrosis. Nature, 505(7481):97-102, 2014 (Epub 2013 Nov 20) (#equal contribution). PMID 24256728


Highlighted in 1) Science Signaling 2014, 7(307):ec7; 2) F1000Prime(article 718183961);

3) Science Translational Medicine 2014, 6(224):ec33. 4) Hepatology2014, doi:10.1002 /hep.27116.

(4).  RafiiS, Cao Z, Lis R, Chavez D, Shido K,Rabbany SY, Ding BS. Platelet-derivedSDF-1 primes the pulmonary capillary vascular niche to drive lung alveolarregeneration.NatureCell Biology 2015, 17(2):123-36. PMID 25621952


(5).  Cao Z, Fan-Minogue H, Bellovin DI, Yevtodiyenko,Arzeno J, Yang Q, Gambhir SS, Felsher DW. MYC phosphorylation, activation, andtumorigenic potential in hepatocellular carcinoma are regulated by HMG-CoAreductase. Cancer Res. 2011, 71(6): 2286-97. PMID 21262914


(6).  Ding BS, Nolan DJ,Guo P, Babazadeh AO, Cao Z,Rosenwaks Z, Crystal RG, Simons M, Sato TN, Worgall S, Shido K, Rabbany SY,Rafii S. Endothelial-derived angiocrine signals induce and sustain regenerativelung alveolarization. Cell. 2011, 147(3): 539-53.PMID 22036563


(7).  Fan-Minogue H, Cao Z, Paulmurugan R, Chan CT, Massoud TF, FelsherDW, Gambhir SS. Noninvasive molecular imaging of c-MYC activation in livingmice. Proc Natl Acad Sci U S A.2010, 107(36): 15892-7. PMID 20713710


(8).  Cao Z, Wu X, Yen L, Sweeney C, Carraway KL 3rd.Neuregulin-induced ErbB3 downregulation is mediated by a protein stabilitycascade involving the E3 ubiquitin ligase Nrdp1. Mol Cell Biol.2007, 27(6): 3280-8. PMID 17210635


(9).  Yen L, Cao Z, Wu X, Injalla ER, Baron C,Young LJ, Gregg JP, Cardiff RD, Borowsky AD, Sweeney C, Carraway KL 3rd.Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth. Cancer Res. 2006, 66(23):11279-86. PMID 17145873


(10).BallifBA, Cao Z, Schwartz D, Carraway KL 3rd, Gygi SP.Identification of 14-3-3epsilon substrates from embryonic murine brain. J Proteome Res. 2006, 5(9):2372-9 PMID 16944949


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